NoMachine’s own default settings should be suitable for the majority of environments in order to obtain optimal performance. Forcing specific settings for fine-tuning of the performance and display quality usually requires a proper investigation first. Changing node.cfg and server.cfg settings risks introducing unexpected behaviour and I think the NoMachine Support Team is able to suggest the most suitable configuration for these special cases if you are trying to set up your own commercial environment.
Associated reading:
The ProxyExtraOptions and DisplayServerExtraOptions keys in the node configuration file
https://www.nomachine.com/AR02N00877
The server.cfg and node.cfg files explained
https://www.nomachine.com/AR02N00877
You can also search these forums to see in what specific cases these keys have been modified.