I think my setup may be different but it sounds similar…..
Monitor : S271HL Acer Monitor (Local Windows 10 Pro 22H2 setup 100% scale 1920X1080) Standard HD Monitor
NoMachine: Scale to Window, 1920×1080 Resolution Headless mode by stopping display-manager
Also, on a separate note I wish there was a way to force a full screen refresh especially when interlaced artifacts make the screen impossible to read. Shaking the window with the mouse helps though sometimes when this happens.