Thanks for the reply, Tor.
I’ve tried all three modes, and get what looks like the same issue regardless.
Yeah, a scaling issue sounds right. I noticed that the offset between the visible mouse location and the actual location of pointer clicks is larger the farther right the mouse is. So, when the mouse is on the left side of the screen, and as I move it right the offset becomes larger.
I also see the issue if I toggle off full-screen mode.
I have confirmed that the resolution of the monitor is equal to the resolution of the remote machine (3840 x 2160).